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Conditions reported as hereditary in Hungarian Vizslas

  

Since the review in Vizslas Down Under was written in early 2003, Ned Patterson has published his paper on epilepsy in Vizslas, and a condition of myositis and polymyositis with pharyngeal dysphagia and megaoesophagus has been noticed in young Vizslas (that is not masticatory myositis, nor is the condition consistent with previous reports of 'head problems' in Vizslas that were generally cosmetic in nature, were not progressive and were not requiring of veterinary attention).  Both epilepsy and myositis are the subject of further investigation (see here for further details).  

For pdf on vizsla longevity, based on lifespan information on over 200 Australian Vizslas and 600 overseas Vizslas, click here.

    
Condition

Reference to Vizslas with condition

General reference book or article

Disease specific reference

Vizsla specific reference

“Affected” head

 

 

Harris

Atopy (atopic dermatitis, allergic dermatitis)

Padgett

 

Coffman, Pinney

Breed differentiation

 

 

Therion

Calcinosis circumscripta

Padgett

Braund (a)

Scott-Richey Research Centre

Cancer

 

 

Boggs (2nd rev),  Coffman#

Cataracts

Padgett

Whitley

 

Cranial muscular atrophy

 

 

Vizsla Club of America CoE

Craniomandibular osteopathy

Clark, Padgett

 

 

Cryptorchidism &/or monorchidism

 

 

Boggs, Boggs (rev), Boggs (2nd rev), Coffman

Defective toes

 

 

Boggs (rev), Boggs (2nd rev)

Demodicosis, generalised

 

 

Boggs, Boggs#, Boggs (rev), Boggs (2nd Rev)#, Coffman#

Ectropion

 

 

Boggs (2nd rev), Coffman

Entropion

Ackerman, Padgett

Rubin, Whitley

Boggs (rev), Boggs (2nd rev), Coffman, Gottlieb, Gottlieb (2nd), Harris, Vizsla Club of America CoE

Epilepsy, idiopathic

  

Jaggy (1 Vizsla in 125 dogs), Saito ( 1 Vizsla in 32 dogs)

Boggs (rev), Boggs (2nd rev), Burke’s Backyard, Coffman, Gottlieb, Gottlieb (2nd), Harris, Patterson, Pinney, Vizsla Club of America CoE

Factor I (fibrinogen) deficiency

Ackerman, Aiello,  Hoskins & Taboada,  Hoskins, Padgett

Brooks

 

Factor VIII deficiency (Haemophilia A)

Ackerman, Clark,  Foley, Padgett, Willis

Brooks

Boggs (rev), Boggs (2nd rev),  Gottlieb, Harris, Pinney, White

Fragmented coronoid process

Padgett

 

 

Goniodysgenesis/ primary glaucoma

 

BVA/KC/ISDS

  

Haemangiosarcoma, cutaneous (Angiosarcoma, cutaneous)

Aiello

Goldschmidt

 

Head deformity

 

 

Hitchmough

Heart defects

 

 

Burke’s Backyard

Hepatoid gland tumour

 

Goldschmidt

 

Hip dysplasia

Ackerman, Padgett, Willis, Clark (incidence low)

 

Boggs, Boggs (rev),  Boggs (2nd rev), Burke’s Backyard, Coffman, Gottlieb, Gottlieb (2nd), Harris, Pinney, White, Vizsla Club of America CoE

Histiocytoma

 

Goldschmidt

Boggs (rev) (no greater frequency in Vizslas than in other breeds), Boggs (2nd rev)#

Hypoadrenocorticism (Addison’s disease)

 

 

Boggs (2nd rev)#

Hypomyelination

Aiello

 

 

Hypothyroidism

Padgett

Nachreiner (Vizslas neither increased nor decreased risk)

Boggs (2nd rev)#

Idiopathic facial nerve paralysis

Clark, Padgett

 

 

Idiopathic thrombocytic purpura (Immune-mediated thrombocytopenia)

Padgett

 

 

Immune-mediated diseases of blood

 

Dodds

 

Lymphoma

 

 

Boggs (2nd rev)

Malocclusion (Bite, incorrect)

 

 

Boggs (rev), Boggs (2nd rev), Coffman, Gottlieb

Mammary Gland Tumours

 

 

Boggs (2nd rev)

Mast Cell Tumour

 

 

Boggs (2nd rev)

Melanoma (melanocytoma)

Aiello

Goldschmidt

Boggs (rev)

Osteochondrosis – shoulder

Ackerman*, Padgett

 

Harris

Pemphigus foliaceous

Padgett

 

 

Progressive Retinal Atrophy

Ackerman, Padgett

Rubin, Whitley

Vizsla Club of America CoE

Sebaceous Adenitis (Granulomatous Sebaceous Adenitis)

Ackerman, Clark, Hoskins, Padgett

Gunter

Boggs (2nd rev)#

Skin lumps not already listed;
   button type tumour

 

 

Boggs

Skin lumps not already listed;
   eyelid tumours

 

 

Boggs, Boggs (2nd rev)#

Skin lumps not already listed;
   lipomas

 

 

Boggs (rev), Boggs (2nd rev) & (2nd rev)#

Skin lumps not already listed;
   sebaceous cyst/adenoma

  

 

Boggs (rev), Boggs (2nd rev)#

Skin lumps not already listed;
   warts

  

 

Boggs (rev)

Skin rash of puppies (“Vizsla rash”)

  

 

Boggs#, Coffman#, Gottlieb,  Gottlieb (2nd), Harris

Skull defects

  

 

Boggs (rev), Boggs (2nd rev), Coffman

Soft Tissue Sarcomas

  

 

Boggs (2nd rev)

Squamous cell carcinoma

  

 

Boggs (2nd rev)

Tail defects

  

 

Boggs (rev), Boggs (2nd rev), Gottlieb, Gottlieb (2nd), White 

von Willebrand Disease

Ackerman, Padgett

 

Boggs (rev), Boggs (2nd rev),  Coffman, Pinney, White, Vizsla Club of America CoE

XX Sex reversal

  

Meyers-Wallen, Meyers-Wallen et al

    

Notes:

* “anecdotally reported as important in the breed, but not reported in literature.”
# not discussed under hereditary conditions, but elsewhere in text.  Included here because other authors or previous editions have considered condition as hereditary.

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General References:

Ackerman L.  The Genetic Connection: A guide to health problems in purebred dogs.  AAHA Press, Lakewood, 1999.
      “The table is not meant to be all inclusive and does not reflect true prevalence of traits.  It should be considered a starting point when evaluating heritable conditions of specific purebreds.”
     Diseases listed as occurring in breeds sourced from peer-reviewed scientific literature and veterinary textbooks.

Aiello SE (ed.) The Merck Veterinary Manual, 8th edition. Merck & Co, Whitehouse Station, 1998.

Clark RD, Stainer JR.  Medical & genetic aspects of purebred dogs.  2nd edition.  Forum Publications, Fairway 1994  p531-532 and p654.

Foley CW, Lasley JF, Osweiler GD.  Abnormalities of companion animals: analysis of heritability.  Iowa State University Press, Ames, Iowa. 1979.  p3-31.
      “The following conditions have been listed as most common in this over other breeds/and/or at least has been reported.”

Hoskins JD, Taboada J.  Congenital defects of the dog.  The Compendium 1992; 14(7): 873-897.
     Congenital conditions are present at birth and may be genetic or result from other factors that occurred during gestation.

Hoskins JD.  Veterinary Pediatrics:  dogs and cats from birth to six months.  3rd edition.  WB Saunders Company, Philadelphia 2001.

Padgett GA.  Control of Canine Genetic Diseases.  Howell Book House, New York, 1998.
     The list of conditions is derived from a report of the incidence of the disease once, or more, in a breed.  If this same disease has been "reported as being genetic" in other breeds or other species, Padgett considers it genetic in the breed.  Padgett does say that as a result of his broad definition, some errors will have occurred - but they are errors on the side of preventing dissemination of the problem, rather than those of omission.
     The list was drawn up from reports of conditions obtained from the Veterinary Medicine Database (VMDB – a computer database obtaining information on all cases presented to 23 veterinary teaching hospitals in North America), from admissions to Michigan State University, from scientific literature and from books such as Willis, Clark, Rubin, Morgan, and the Merck Veterinary manual (all also listed here). 

Willis MB.  Genetics of the Dog.  Howell Book House, New York, 1989.
     References sourced from peer-reviewed scientific literature and textbooks.

  

Disease specific references

Braund KG (a). Degenerative and compressive structural disorders.  In: Braund KG (ed) Clinical neurology in small animals – localization, diagnosis and treatment.  International Veterinary Information Service (www.ivis.org), Ithaca, 2002; B0218.1202  Accessed December 2002.

Brooks, M.  A review of canine inherited bleeding disorders: biochemical and molecular strategies for disease characterization and carrier detection.  J. Hered 1999; 90(1): 112-118

British Veterinary Association/Kennel Club/International Sheep Dog Society (BVA/KC/ISDS) eye scheme
http://www.the-kennel-club.org.uk/health_issues/table2.htm  Accessed December 2002.

Dodds WJ.  Immune-mediated diseases of the blood.   Adv Vet Sc Comp Med 1983; 27: 163-.

Goldschmidt MH, Shofer FS.  Skin tumors of the dog and cat.  Butterworth-Heinemann, Oxford 1998.

Gunter MJ.  Inflammatory skin diseases.  In: Morgan RV, Bright RM and Swartout MS (eds).  Handbook of small animal practice.  4th edition.  Saunders, Philadelphia, 2003. p860-861

Jaggy A, Bernardini M.  Idiopathic epilepsy in 125 dogs: a long term study.  Clinical and electroencephalographic findings.  J Small Anim Pract 1998; 39: 23-29

Meyers-Wallen VN.  Inherited abnormalities of sexual development in dogs and cats.  In: Concannon PW, England G, Verstegen J, Linde-Forsberg C (eds) Recent advances in small animal reproduction.  International Veterinary Information Service (www.ivis.org), Ithaca, 2001; A1217.0901  Accessed September 2001.

Meyers-Wallen VN, Schlafer D, Barr I, Lovell-BadgeR, Keyzner A.  Sry-Negative XX sex reversal in purebred dogs.  Mol Reprod Dev 1999; 53: 266-273.

Nachreiner RF, Refsal KR, Graham PA, Bowman MM.  Prevalence of serum thyroid hormone autoantibodies in dogs with clinical signs of hypothyroidism.  J Am Vet Med Assoc 2002; 220: 466-471

Rubin LF.  Inherited eye diseases in purebred dogs.  Williams & Wilkins, Baltimore, 1989.

Saito M, Munana KR, Sharp NJH, Olby NJ.  Risk factors for development of status epilepticus in dogs with idiopathic epilepsy and effects of status epilepticus on outcome and survival time: 32 cases (1990-1996).  J Am Vet Med Assoc 2001; 219(5): 618-623.

Whitley RD, McLaughlin SA, Gilger BC.  Update on eye disorders among purebred dogs.  Vet Med 1995; 90: 574-592
      “This article provides a list of breed dispositions from current veterinary ophthalmic texts, journal articles, newsletters, communication with colleagues and personal experience…  Although we suspect these disorders are inherited, inheritance has not been proven in all instances.”

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Vizsla specific references

Boggs BC.  The Vizsla.  Glenbrier Publishing Company, Jackson, 1973.

Boggs BC.  The Vizsla.  Revised edition. Glenbrier Publishing Company, Jackson, 1982. (Boggs rev)

Boggs BC.  The Vizsla.  Second revised edition.  Behi Publishing Company, Brown & Kroger Printing Company, Miamisburg, 2000.  (Boggs 2nd rev)

Burke’s Backyard Hungarian Vizsla fact sheet.  http://www.burkesbackyard.com.au/facts/1999/roadtests/hungarianvizsla_39.html  Accessed December 2002.

Coffman MI.  Versatile Vizsla.  Alpine publications, Loveland 1991.

Gottlieb G.  The complete Hungarian Vizsla.  Ringpress books, Letchworth, 1992.

Gottlieb G.  The Hungarian Vizsla.  2nd edition.  Kingdom Books, England, 1999. (Gottlieb 2nd)

Harris F.  The Hungarian Vizsla in Australia, Thomsons Printing, Albury, 1992.

Hitchmough R.  “Head deformities in the Vizsla”.  Vizsla News, Nov/Dec 1988, reprinted July, 1993.

Patterson EE, Mickelson JR, Da Y, Roberts MC, McVey AS, O’Brien DP, Johnson GS, Armstrong PJ.  Ascertainment corrected segregation analysis of idiopathic epilepsy in Vizslas.  ACVIM Proc 2002.

Pinney CC.  Vizslas.  Everything about purchase, care, nutrition, grooming, behavior and training. Barron’s, Hong Kong, 1998.

Scott-Richey Research Centre, college of Veterinary Medicine. Auburn University.  http://www.vetmed.auburn.edu/srrc/vizsla.htm   Accessed December 2002.

Therion corporation.  http://www.theriondna.com/   Accessed January 2003.

Vizsla Club of America, Code of Ethics – http://clubs.akc.org/vizsla/ethics.htm  Accessed December 2002.

White RL.  Hungarian Vizsla.  Interpet publishing, Dorking, 2000.

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Other references used in the text of the chapter in relation to the conditions listed in the table:

Oz Dog Hungarian Vizsla profile.  http://www.dogzonline.com.au/ozdog/profiles/vizsla.htm  Accessed December 2002.

Vizsla Club of America health survey.  http://clubs.akc.org/vizsla/healthsurvey.htm  Accessed December 2002.

Club Code of Ethics:
     Hungarian Vizsla Club (United Kingdom) –  http://www.hungarianvizslaclub.org.uk/  Accessed December 2002.
     Hungarian Vizsla Society (United Kingdom) – http://www.vizsla.org.uk/  Accessed December 2002.

   

Andrew SE.  Diseases of eyelids.  In: Morgan RV, Bright RM and Swartout MS (eds).  Handbook of small animal practice.  4th edition.  Saunders, Philadelphia, 2003. p930-932

Berendt M, Gram L.  Epilepsy and seizure classification in 63 dogs: a reappraisal of veterinary epilepsy terminology.  J Vet Intern Med 1999; 13: 14-20.

Berendt M, Gredal H, Gam Pedersen L, Alban L, Alving J.  A cross-sectional study of epilepsy in Danish Labrador retrievers: prevalence and selected risk factors.  J Vet Intern Med 2002; 16: 262-268.

Braund KG (b).  Myopathic disorders.  In: Braund KG (ed) Clinical neurology in small animals – localization, diagnosis and treatment.  International Veterinary Information Service (www.ivis.org), Ithaca, 2002; B0221.1202  Accessed December 2002.

British Veterinary Association/Kennel Club Hip Dysplasia scheme http://www.bva.co.uk/about/canine.html  Accessed December 2002.

Canine Eye Registration Foundation (CERF) testing 2000.  http://www.vmdb.org/feb01.html  Accessed December 2002.

Day MJ and Bennett D. Immune-mediated musculoskeletal and neurological disease.  In:  Day MJ (ed).  Clinical Immunology of the dog and cat.  Manson Publishing, London, 1999.

Famula TR, Oberbauer AM.  Segregation analysis of epilepsy in the Belgian tervueren dog.  Vet Rec 2000; 147: 218-221

Fox PR, Sisson D, Moise NS (eds).  Textbook of canine and feline cardiology.  2nd edition. WB Saunders, Philadelphia, 1999.

Hall SJG, Wallace ME.  Canine epilepsy: a genetic counselling programme for keeshonds.  Vet Rec 1996; 138:358-360

Jaggy A, Faissler D, Gaillard C, Srenk P, Graber H.  Genetic aspects of idiopathic epilepsy in Labrador retrievers.  J Small Anim Pract 1998; 39: 275-280

Jagielski D, Lechowski R, Hoffman-Jagielska M, Winiarczyk S.  A retrospective study of the incidence and prognostic factors of multicentric lymphoma in dogs (1998-2000).  J Vet Med A 2002; 49(80: 419-424.

Kathmann I, Jaggy A, Busato A, Bärtschi M, Gaillard C.  Clinical and genetic investigations of idiopathic epilepsy in the Bernese mountain dog.  J Small Anim Pract 1999; 40: 319-325

Kiss G, Radvany Sz, Szigeti G.  New combination for the therapy of canine otitis externa.  J Small Anim Pract 1997; 38; 51-56

LaFond E, Breur GJ, Austin CC.  Breed susceptibility for developmental orthopedic diseases in dogs.  J Am Anim Hosp Assoc 2002; 38: 467-477

             Cases presented between January 1986-December 1995 to hospitals participating in Veterinary Medicine Database.  Vizslas not predisposed to hip dysplasia, CMO, fragmented coronoid process, osteochondrosis of the elbow, shoulder, stifle or tarsus, patella luxation, ununited anconeal process, panosteitis, hypertrophic osteodystrophy or Legg-Calve-Perthes disease.

Larocca RD.  Disorders of the posterior segment.  In: Morgan RV, Bright RM and Swartout MS (eds).  Handbook of small animal practice.  4th edition.  Saunders, Philadelphia, 2003. p1006-1008

Lower K, Swartout MS.  Neoplasia of the skin.  In: Morgan RV, Bright RM and Swartout MS (eds).  Handbook of small animal practice.  4th edition.  Saunders, Philadelphia, 2003. p914-926

Munjar TA, Austin CA, Breur GJ.  Comparison of risk factors for hypertrophic osteodystrophy, craniomandibular osteopathy and canine distemper virus infection.  Vet Comp Orthop Traumatol 1998; 11: 37-43.

             No Vizslas diagnosed with CMO in 68 cases of the condition presented through Veterinary Medicine Database scheme, between 1980-1989.

Podell M.  Inflammatory myopathies.  In: Shelton GD (ed). Neuromuscular diseases.  Vet Clinics Nth Am Sm Anim Pract 2002; 32(1): 147-167

Reichler IM, Hauser B, Schiller I, Dunstan RW, Credille KM, Binder H, Glaus T, Arnold S.  Sebaceous adenitis in the Akita: clinical observations, histopathology and heredity.  Vet Dermatol 2001; 12: 243-253

Shelton GD, Cardinet GH.  Canine masticatory muscle disorders.  In: Kirk RW (ed) Kirk’s Current Veterinary Therapy X, WB Saunders, Philadelphia 1989.  p816-819

Smith SH, Goldschmidt MH, McManus PM.  A comparative review of melanocytic neoplasms.  Vet Pathol 2002; 39: 651-678

Sousa CA, Marsella R.  The ACVD task force on canine atopic dermatitis (II): genetic factors.  Vet Immunol Immunopathol 2001; 81: 153-175

Taylor SM.  Selected disorders of muscle and the neuromuscular junction.  In: Thomas WB (ed). Common Neurologic problems. Vet Clinics Nth Am Sm Anim Pract 2000; 30(1): 60-62

Thomas WB.  Idiopathic epilepsy in dogs.  In: Thomas WB (ed). Common Neurologic problems. Vet Clinics Nth Am Sm Anim Pract 2000; 30(1): 183-206.

University of Melbourne Veterinary Clinic and Hospital, Clinical Pathology laboratory.

Ward CR.  Diseases of the thyroid.  In: Morgan RV, Bright RM and Swartout MS (eds).  Handbook of small animal practice.  4th edition.  Saunders, Philadelphia, 2003. p456-458

Whitehair JG, Vasseur PB, Willits NH.  Epidemiology of cranial cruciate ligament rupture in dogs.  J Am Vet Med Assoc 1993; 203(7): 1016-1019

Whittick WG.  Canine orthopedics.  2nd edition.  Lea & Febiger, Malvern, 1990.

Zur G, Ihrke PJ, White SD, Kass PH.  Canine atopic dermatitis: a retrospective study of 266 cases examined at the University of California, Davis, 1992-1998.  Part I.  Clinical features and allergy testing results.  Vet Dermatol.  2002; 13: 89-102.

  

 Extract from:  Orzeszko, K.  Hereditary Disease in the Hungarian Vizsla.
 In:  Vizslas down Under™  1999-2001

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