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  Prostate problems in dogs

Not Vizsla specific - but to clear some common misconceptions;  Castration of a dog will not prevent prostate cancer, and it has been reported that the risk of prostatic cancer may be increased in neutered males [1,2,6].  Castration by removal of the testes will only prevent two things - your dog cannot get cancer of the testes, and he cannot become a father.  However, most 'prostate problems' are more common in entire dogs than in castrated males. What do we mean by 'prostate problems'?

Possible prostate problems
•  enlargement of the prostate, or benign prostatic hyperplasia (BPH)
•  inflammation of the prostate, or prostatitis
•  prostatic cysts
•  cancer of the prostate

Benign Prostatic Hyperplasia (BPH).  Having BPH does not mean your dog will necessarily have symptoms of prostatic problems. By the age of 5, studies have found between 60-90 % plus of entire dogs have BPH. Human men also develop BPH, and the number of BPH affected dogs and humans increases with increasing age. In men, as the prostate enlarges, it presses on the urethra, resulting in the well-known drippy plumbing problem. In dogs, the growth doesn't usually affect the prostatic urethra in this way (but may), most commonly pressing on the bowel instead. This results in thinner, or ribbon-like stools. Castration of a male dog prevents BPH from occurring, and is also the way to cure it.  This is because the size of the male prostate is dependent upon androgens. Removal of androgen source, either by chemical or physical castration, results in involution, or shrinkage, of the gland. Although up to 90% plus of entire dogs can have BPH, they do not necessarily have any problems associated with this.

Prostatitis or inflammation of the prostate is 'fairly common' in dogs, and may present as an emergency. Prostatitis is far less frequent in neutered dogs than entire dogs. Infection can be acute or chronic, and abscesses may also occur. In chronic cases, permanent castration is a treatment-prevention choice as it helps prevent recurrence.

Numerous types of prostatic cysts can occur in dogs. Some may be an extension of benign hyperplasia, or they may be a true cyst. Large cysts can be drained and surgically removed. Neutering may be recommended to decrease chances of recurrence.

Cancer of the prostate is not really that common in dogs. By comparison, in humans it is the 2nd leading cause of cancer in men in the US.  Like many cancers, cancer of the prostate is more likely to be found in older dogs, median age 10 years, though it has been reported in dogs as young as 4 and as old as 17.  Screening tests for prostatic disease by measuring blood levels of prostate-specific antigen (PSA) as occurs in humans, is not useful in dogs.  Diagnosis is usually late in the course of the disease and life expectancy of a dog diagnosed with cancer of the prostate is not very long - University of Minnesota College of Veterinary Medicine report a maximum survival of 5 months for dogs treated with radiation therapy [3].  Having said it is uncommon, in a study of 35 dogs without signs of prostatic disease, Waters et al [4] found one dog with carcinoma of the prostate, so it may be more common than currently reported in the absence of appropriate methods of detection. It has also been suggested [5] the majority of prostate cancers in dogs have been misclassified, thus affecting our ability to establish risk or contributing factors. As stated above, castration does not prevent cancer of the prostate from occurring, and recent papers [1,2,6] have found an increased risk for prostate cancer in neutered dogs, and in the Bouvier des Flandres breed [1].

References:
1.  Teske E, Naan EC, van Dijk EM, Van Garderen E, Schalken JA  Mol Cell Endocrinol 2002; 197(1-2): 251-255.
2.  Sorenmo KU, Goldschmidt M, Shofer F, Goldkamp C, Ferracone J. Immunohistochemical characterization of canine prostatic carcinoma and correlation with castration status and castration time.  Vet Comp Oncol 2003; 1(1): 48-56.
3.  Johnston SD, Kamolpatana K, Root-Kustritz MV and Johnston GR.  Anim Reprod Sc 2000; 60-61: 405-415.
4.  Waters DJ, Bostwick DG. J Urol 1997; 157: 713-716.
5.  Kennedy PC, Cullen JM, Goldschmidt MH, Larsen S, Munson L, Nielsen S, editors. Histological Classification of Tumors of the Genital System of Domestic Animals. Second Series. Washington D.C.: Armed Forces Institute of Pathology; 1998.
6.  Bryan JN, Keeler MR, Henry CJ, Bryan ME, Hahn AW and Caldwell CW.  Prostate 2007; 67(11):1174-1181.

Note: the above information is not intended as a substitute for veterinary advice.

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Revised: 06 January, 2008